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KMID : 0380020190340040338
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Korean Journal of Biotechnology and Bioengineering
2019 Volume.34 No. 4 p.338 ~ p.345
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Complex Effect of Saw palmetto Extract and Rhodiola Sachalinesis Extract on Prostatic Hyperplasia Epithelial Cells (BPH-1)
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Kwon Mi-Jin
Cho Young-Ho
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Abstract
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This study was conducted to evaluate whether Rhodiola sachalinesis extract (RS) is effective in reducing Saw palmetto extract (SP)-induced toxicity and improving benign prostatic hyperplasia (BPH). RS powder was extracted with 50% ethanol to prepare an extract. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2-diphenyl-1-picrylhydrazyl (ABTS) radical scavenging activities for RS extract were 8.7 μg/mL and 2.5 μg/mL, respectively. Toxicity to testicular cells, normal prostate cells and BPH-1 by SP or RS alone treatment and SP-RS combined treatment was tested. As a result, SP showed toxicity in testicular cells and normal prostate cells, whereas RS did not show toxicity in both cells. On the other hand, SP did not show apoptotic effect in BPH-1, but RS-induced apoptosis in BPH-1 in a concentration-dependent manner. In SP-RS complex treatment, the normal intracellular toxicity to SP was weakened, and the cytotoxic effect on BPH-1 was rather increased. These results indicate that RS can be used as a material for BPH improvement because it can induce apoptosis of BPH-1 without toxicity to normal cells, when treated with SP alone or in combination with SP.
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KEYWORD
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Rhodiola sachalinesis, Saw palmetto, benign prostatic hyperplasia, toxicity, testicular cells
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